Amino Acid-Derived Radiotracer Compounds for PET Cancer Imaging
Application
New class of fluorine-18 labeled amino acid-derived radiotracer compounds for positron emission tomography (PET) cancer imaging.
Key Benefits
Next generation of cancer imaging agents.
Enhanced sensitivity to detect glioblastoma, prostate cancer and other cancers.
Market Summary
PET imaging is a type of nuclear medicine procedure...
Published: 3/19/2024
Contributor(s): Mark Goodman, Lanny Liebeskind, Thomas Pickel
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Organocatalysts for Amide Bond Formation
ApplicationChemically catalyzed amide bond formation under mild reaction conditions.Key BenefitsEnables amide bond formation under mild reaction conditions.Organocatalyst are easily synthesized.Avoids the use and disposal of hazardous chemicals.Market SummaryAmide bonds are very frequently incorporated into active pharmaceutical ingredients (API). Amide...
Published: 11/27/2023
Contributor(s): Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Sri Rama Murthy Akondi, Vidyavathi Patro, Nikolay Orlov
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Desulfitative Redox Catalysis Method for Production of Amide and Peptide Linkages
ApplicationAn efficient and economic catalytic process for forming amide and peptide compounds.Key BenefitsUses more inexpensive reagents compared to other methods.Amide/peptide bond is generated in high yield at or near ambient temperature.Mild reaction conditions prevent generation of impurities.Market SummaryPeptide and amide linkages are important...
Published: 11/27/2023
Contributor(s): Lanny Liebeskind, Matthew Lindale
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Small Molecule Potentiators of NMDA Receptors for Treating Neurological Conditions
Application
Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D.
Key Benefits
Small molecule potentiators enhance endogenous signals without exogenous activation.
Subunit selectivity allows targeting of specific subtypes of...
Published: 7/28/2023
Contributor(s): Dennis Liotta, Ethel Garnier-Amblard, Gabriela Fernandez-Cuervo, Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Stephen Traynelis, Katie Strong, Rose Santangelo-Freel
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Scalable Linkage Formation Boosts Protein Engineering
Application
Efficient scalable method for creating peptide or amide linkages and generating peptides, proteins, or glycoproteins.
Key Benefits
Reactions involved are simple, mild, generalizable, and efficient, potentially reducing production costs.
Starting materials needed for this synthesis can also be produced easily and can be generated in...
Published: 12/7/2023
Contributor(s): Lanny Liebeskind, Wen-ting Wu, Zhihui Zhang, Hao Li, Angus Lamar
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Innovative Method for Bulk Production of Sphingolipids
ApplicationOptically pure D-erythro-Sphingosine that can be produced with high yield.Key Benefits Method efficiently produces D-erythro-Sphingosine and derivatives in bulk and with high optical purity. D-erythro-Sphingosine can be converted to many other sphingolipids for use in the production of therapeutics and cosmetics. Technical Summary Sphingolipids...
Published: 11/6/2023
Contributor(s): Hao Yang, Lanny Liebeskind
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