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Amino Acid-Derived Radiotracer Compounds for PET Cancer Imaging
Application New class of fluorine-18 labeled amino acid-derived radiotracer compounds for positron emission tomography (PET) cancer imaging. Key Benefits Next generation of cancer imaging agents. Enhanced sensitivity to detect glioblastoma, prostate cancer and other cancers. Market Summary PET imaging is a type of nuclear medicine procedure...
Published: 3/19/2024       Contributor(s): Mark Goodman, Lanny Liebeskind, Thomas Pickel
Organocatalysts for Amide Bond Formation
ApplicationChemically catalyzed amide bond formation under mild reaction conditions.Key BenefitsEnables amide bond formation under mild reaction conditions.Organocatalyst are easily synthesized.Avoids the use and disposal of hazardous chemicals.Market SummaryAmide bonds are very frequently incorporated into active pharmaceutical ingredients (API). Amide...
Published: 11/27/2023       Contributor(s): Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Sri Rama Murthy Akondi, Vidyavathi Patro, Nikolay Orlov
Desulfitative Redox Catalysis Method for Production of Amide and Peptide Linkages
ApplicationAn efficient and economic catalytic process for forming amide and peptide compounds.Key BenefitsUses more inexpensive reagents compared to other methods.Amide/peptide bond is generated in high yield at or near ambient temperature.Mild reaction conditions prevent generation of impurities.Market SummaryPeptide and amide linkages are important...
Published: 11/27/2023       Contributor(s): Lanny Liebeskind, Matthew Lindale
Small Molecule Potentiators of NMDA Receptors for Treating Neurological Conditions
Application Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D. Key Benefits Small molecule potentiators enhance endogenous signals without exogenous activation. Subunit selectivity allows targeting of specific subtypes of...
Published: 7/28/2023       Contributor(s): Dennis Liotta, Ethel Garnier-Amblard, Gabriela Fernandez-Cuervo, Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Stephen Traynelis, Katie Strong, Rose Santangelo-Freel
Scalable Linkage Formation Boosts Protein Engineering
Application Efficient scalable method for creating peptide or amide linkages and generating peptides, proteins, or glycoproteins. Key Benefits Reactions involved are simple, mild, generalizable, and efficient, potentially reducing production costs. Starting materials needed for this synthesis can also be produced easily and can be generated in...
Published: 12/7/2023       Contributor(s): Lanny Liebeskind, Wen-ting Wu, Zhihui Zhang, Hao Li, Angus Lamar
Innovative Method for Bulk Production of Sphingolipids
ApplicationOptically pure D-erythro-Sphingosine that can be produced with high yield.Key Benefits Method efficiently produces D-erythro-Sphingosine and derivatives in bulk and with high optical purity. D-erythro-Sphingosine can be converted to many other sphingolipids for use in the production of therapeutics and cosmetics. Technical Summary Sphingolipids...
Published: 11/6/2023       Contributor(s): Hao Yang, Lanny Liebeskind