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DNAzyme Nanoparticles for the Cleavage of RNA
Application
Site-selective RNA splicing nanozyme for cleaving and ligating RNA.
Key Benefits
Can cleave virtually any RNA stem loop.
Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency.
Technical Summary
Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 12/1/2023
Contributor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
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DNA Machines Enhance SNP Analysis Efficiency
Application
DNA-based machines that roll rather than walk and can be used for single nucleotide polymorphism (SNP) analysis.
Key Benefits
Unique "rolling" cogwheel-like mechanism allows directional motion without a track or external guidance.
Micron-sized cargo travels large distances; can be visualized using a smartphone camera equipped with...
Published: 4/8/2024
Contributor(s): Khalid Salaita, Kevin Yehl
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Therapeutic DNAzyme-Nanoparticle Conjugates for Gene Regulation
Application
Catalytic DNA molecules (DNAzymes) conjugated to gold nanoparticles for use as therapeutics to treat cancers, infections or other applications of gene therapy.
Key Benefits
DNAzyme-gold nanoparticles regulate gene expression through an RNAi independent mechanism.
Each DNAzyme-gold nanoparticle is more catalytically active than a free...
Published: 7/28/2023
Contributor(s): Khalid Salaita, Kevin Yehl
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