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Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma
Application
A small molecule compound to treat Malignant Glioblastoma multiforme.
Key Benefits
Dual inhibition of NQO1 and GSTP1 induces cell death in glioblastoma cells.
Inhibition of NQO1 and GSTP1 by MNPC suppresses tumor growth and elongates the life span of the animals with GBM.
Market Summary
Approximately 30% of patients diagnosed with...
Published: 4/23/2024
Contributor(s): Keqiang Ye
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Antibodies for α-Synuclein Cleavage by Asparagine Endopeptidase (AEP) and Activated AEP
Application
ELISA
Western Blot
Immunohistochemistry
Subtype
Rabbit polyclonal
Technical Summary
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. It is characterized by the loss of predominately dopamine-producing neurons in a specific area of the brain called substantia nigra. α-Synuclein...
Published: 4/23/2024
Contributor(s): Keqiang Ye
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7,8-Dihydroxyflavone Derivatives for Treating Neurological and Neurodegenerative Diseases
Application
Family of small molecule 7,8-dihydroxyflavones that act as TrkB agonists, including a prodrug, for treating a number of neurological conditions and diseases.
Key Benefits
Has antidepressant-like properties, improves cognitive function, and promotes neuronal survival in animal models of neurological diseases.
Whereas current anti-depressant...
Published: 7/28/2023
Contributor(s): Keqiang Ye
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Rabbit Polyclonal Antipike Antibody
Application
Immunoblotting
Immunoprecipitation
Immunofluorescence
Specificity
Rabbit Polyclonal Anti-PIKE Antibody
Subtype
Anti-Rabbit
Technical Summary
PIKE-activating Akt (PIKE-A), an isoform of PIKE GTPase that enhances phosphatidyl- inositol 3-kinase (PI3-kinase) activity. PIKE will specifically binds to active Akt but not PI3-kinase....
Published: 4/23/2024
Contributor(s): Keqiang Ye
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