Technology Listings


21 Results Sort By:
Antibodies for α-Synuclein Cleavage by Asparagine Endopeptidase (AEP) and Activated AEP
ApplicationELISAWestern BlotImmunohistochemistrySubtypeRabbit polyclonalTechnical SummaryParkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. It is characterized by the loss of predominately dopamine-producing neurons in a specific area of the brain called substantia nigra. α-Synuclein is a component of ...
Published: 1/21/2018       Inventor(s): Keqiang Ye
Asparagine Endopeptidase (Legumain) Inhibitors for Treating Cancers
ApplicationSmall molecule inhibitors of asparagine endopeptidase for the treatment of cancers. Key BenefitsNontoxic and specific inhibitors selectively block asparagine endopeptidase (AEP), leaving other related cysteine proteases unaffected.Effectively represses the metastasis of breast cancer cells to lungs.Market SummaryAsparagine endopeptidase ...
Published: 10/25/2016       Inventor(s): Keqiang Ye, Haian Fu, Yuhong Du
Asparagine Endopeptidase (Legumain) Inhibitors for Treating Neurological Disorders
ApplicationSmall molecule inhibitors of asparagine endopeptidase for the treatment of neurological disorders. Key BenefitsNontoxic and specific inhibitors selectively block asparagine endopeptidase (AEP), leaving other related cysteine proteases unaffected.Alzheimer’s candidate is blood-brain barrier permeable.Market SummaryNearly 36 million ...
Published: 10/25/2016       Inventor(s): Keqiang Ye, Haian Fu, Yuhong Du
7,8-Dihydroxyflavone Derivatives for Treating Neurological and Neurodegenerative Diseases
Application Family of small molecule 7,8-dihydroxyflavones that act as TrkB agonists, including a prodrug, for treating a number of neurological conditions and diseases. Key Benefits Has antidepressant-like properties, improves cognitive function, and promotes neuronal survival in animal models of neurological diseases. Whereas current anti-depre...
Published: 10/18/2016       Inventor(s): Keqiang Ye
Antibodies that Bind to Amyloid Precursor Protein (APP) Peptides
ApplicationELISA Western Blot Immunohistochemistry SpecificityRabbit PolyclonalTechnical SummaryAlzheimer’s disease is the most common form of severe dementia; yet, there is no cure. Although it is known that Amyloid b (Ab) plaques contribute to the disease, additional research tools are necessary to determine how these plaques form. Research...
Published: 3/17/2016       Inventor(s): Keqiang Ye
Antibody That Binds to Asparagine Endopeptidase-Cleaved Type of Tau
Applications ELISA Western Blot Immunohistochemistry Specificity Human, Mouse Subtype Rabbit Monoclonal Technical Summary Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by extracellular senile plaque deposits, composed of amyloid beta and intracellular Neurofibrillary tangles (NFT), made of truncated and...
Published: 2/8/2016       Inventor(s): Keqiang Ye
Quantitative ELISA for Determination of TrkB Activation
Application A quantitative enzyme-linked immunosorbent assay (ELISA) for monitoring endogenous rat tyrosine receptor kinase B (TrkB) activation. Key Benefits Two quantitative ELISA approaches provide reliable methods to quantify the intensity of TrkB receptor activation in primary neurons with endogenous TrkB receptor. Enables high-throughput dr...
Published: 4/27/2015       Inventor(s): Keqiang Ye
TrkA and TrkB Stably Transfected Murine Cell Lines
Application Cell lines (T17, T48, and T62) to screen for TrkA and/or TrkB agonists. Technical Summary Neurotrophins play an essential role in the development and maintenance of the nervous system. One such neutrophin, nerve growth factor (NGF) binds mainly tyrosine kinase A (TrkA). Docking of TrkA by NGF initiates receptor dimerization, phosphoryl...
Published: 6/6/2013       Inventor(s): Keqiang Ye
The Antitussive Drug Noscapine & its Derivatives as Anti-Tumor Agents
Application Can be used for the treatment of neoplastic disease. Summary A variety of chemotherapeutic agents interact with tubulin, the major protein of mitotic spindles, resulting in mitotic arrest and ultimately cell death in rapidly dividing cells. Athough tubulin-targeting agents are capable of arresting cells in mitotis, these drugs indiscrim...
Published: 6/6/2013       Inventor(s): Harish Joshi, Judith Kapp, Yong Ke, Fuqiang Liu, Keqiang Ye, Jaren Landen, David Archer, Cheryl Armstrong
Pike-A Polyclonal Antibody (Non-Phospho)
Applications Western Blot Immunohistochemistry Specificity Mouse PIKE-A Subtype Rabbit polyclonal Technical Summary PIKE-A is a ubiquitously expressed GTPase. Expression of PIKE-A enhances Akt activity and promotes invasiveness of cancer cell lines, while knockdown of PIKE-A decreases Akt activity and increases apoptosis. PIKE-A overexpression...
Published: 11/12/2012       Inventor(s): Keqiang Ye
1 2 3