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Small Molecule Inhibitors of NADPH Oxidase 4 (NOX4) Signaling
Application Small molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential. Key Benefits Small molecule inhibitors of NOX4 signaling. Low cytotoxicity. Market Summary The NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of...
Published: 12/1/2023       Contributor(s): Bernard Lassegue, Kathy Griendling, David Brown, Qian Xu, Osman Guner, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
Targeted Drug Development for Abnormal Proliferation
Applications Target for drug development for diseases involving abnormal proliferation of cells, including psoriasis (hyperproliferation of skin cells) and benign prostatic hypertrophy. Technical Summary Reactive oxygen intermediates (ROI) are generated during an oxidative process that occurs in many cell types. The result of generating reactive...
Published: 11/27/2023       Contributor(s): John David Lambeth, Bernard Lassegue, Kathy Griendling, Rebecca Arnold, Guang Cheng