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Class of Bcl-2 Inhibitors as Anti-Cancer Therapeutics
Application Small molecule inhibitors of Bcl-2, an anti-apoptotic protein, for cancer treatment. Key Benefits Developed specifically to target the BH4 homology domain of Bcl-2 in order to improve binding affinity and anti-tumor efficacy over other Bcl-2 inhibitors. Compounds may simultaneously suppress a wider range of anti-apoptotic proteins...
Published: 12/7/2023       Contributor(s): Xingming Deng, Jia Zhou, Chunyong Ding
Bax Activators as Highly Selective Anti-Tumor Agents
Application Therapeutic for treatment of cancer. Key Benefits The first in class, potent and selective agonists of Bax with nanomolar activity. Bax activators have significantly less apoptotic effect on normal cells as compared to cancer cells. Compounds have shown high selectivity for tumor cells. Technical Summary Patients with cancer have...
Published: 3/1/2024       Contributor(s): Xingming Deng, Jia Zhou, Chunyong Ding