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Vaccine-pulsed Dendritic Cells as a Treatment for Aggressive Breast Cancers
Application
Immunotherapy for HER2+ and triple-negative breast cancer.
Key Benefits
Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers.
Prepared outside of the body and then administered to patients.
Preclinical data indicate treatment decreases tumor growth and improves...
Published: 4/8/2024
Contributor(s): Periasamy (Selva) Selvaraj, Luis Munoz, Ramireddy Bommireddy, Christopher Pack, Shaker Reddy, Sampath Ramachandiran
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Method for Identifying and Optimizing the Development of Heterodimeric Monoclonal Antibodies
Application
Method to generate IgG heterodimers that can be used to generate bi-specific monoclonal antibodies for disease treatment.
Key Benefits
A novel method of screening and developing novel IgG heterodimers used for generating monoclonal antibodies for many diseases.
Preliminary data demonstrate efficient production of IgG heterodimers that...
Published: 3/1/2024
Contributor(s): Eric Sundberg, Jonathan Du, Tala Azzam
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Engineering Asymmetrically Glycosylated IgG Antibodies
Application
A novel method to develop asymmetrically glycosylated therapeutic monoclonal IgG antibodies for preventing and treating diseases like cancer, infectious diseases, and autoimmune disorders.
Key Benefits
Different IgG antibody glycoforms can be produced, each with its unique effector functions and biological and therapeutic effects.
Potential...
Published: 3/1/2024
Contributor(s): Eric Sundberg, Jonathan Du, Tala Azzam
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Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System
Application
Protein-based therapeutics for the treatment of IgG-mediated diseases.
Key Benefits
A new class of endoglycosidases for the treatment of IgG-mediated diseases.
Four novel compounds have been developed that exhibited robust in vitro activity.
Potential to become first-in-class medications for dysregulation of the adaptive immune system,...
Published: 4/9/2024
Contributor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos
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Vital Sign Trajectory Algorithm
Application
A precision medicine algorithm that reduces mortality in sepsis patients by individualizing and targeting specific therapies to specific patients.
Key Benefits
An algorithm that uses bedside routine vital signs to optimize the precision treatment of sepsis.
Clinical data show the ability of the algorithm to identify a subset of patients...
Published: 3/11/2024
Contributor(s): Sivasubramanium (Siva) Bhavani
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Total Ankle Arthroplasty Design
Application
An intra-articular alignment guide for ankle replacement system to treat ankle arthritis.
Key Benefits
Less invasive method that does not require drilling a hole through the heel for Inbone II tibial stem placement.
More convenient to use compared to Inbone II frame and foot holder to find the correct alignment.
Market Summary
Approximately...
Published: 9/15/2023
Contributor(s): Rishin Kadakia
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Improving Pediatric Asthma Management for Urban Families
Application
Home-based family psychoeducational intervention for low-income children with persistent asthma.
Key Benefits
Medical and psychosocial needs of patients and family members can be addressed simultaneously.
Significantly improved asthma management and caregiver stress in randomized controlled clinical trial.
Market Summary
Asthma...
Published: 7/28/2023
Contributor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
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Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application
Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage.
Key Benefits
Currently there is no method to determine if an MSC donor line will be therapeutically effective.
Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 4/10/2024
Contributor(s): Nick Willett, Levi Wood, Jay McKinney
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Novel Piperidine-Amide Derivatives as CXCR4 Modulators
Application
A new class of CXCR4 modulators for metastasis and inflammation.
Key Benefits
Selective for only one allosteric site on CXCR4.
Lower adverse effects.
Market Summary
Activation of the CXCR4 receptor triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone...
Published: 11/27/2023
Contributor(s): Hyunsuk Shim, Yoon Hyeun Oum
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HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
Application
High Throughput Screening for identifying effective immuno-modulators.
Key Benefits
HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents.
Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 12/1/2023
Contributor(s): Xiulei Mo, Haian Fu
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