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Glycoprotein Tetramer for Identifying Antigen-specific B Cells
ApplicationEctodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.Key BenefitsViral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.Market SummaryHepatiti...
Published: 5/9/2019       Inventor(s): Arash Grakoui, Joseph Marcotrigiano
IFN╬│ Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
ApplicationMesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.Key BenefitsPreserves the immunosuppressive function of MSCs following thawing.Improves effectiveness of transplanted MSCs following cryopreservation.Market SummaryMesenchymal strom...
Published: 1/22/2019       Inventor(s): Jacques Galipeau, Raghavan Chinnadurai
Specialized Cell Culturing Media for Enhanced Antibody Secretion and Plasma Cell Survival
ApplicationCell culture media that promotes the survival of human plasma cells and enables immunoglobin (Ig) secretion from such plasma cells.Key BenefitsFacilitates the isolation of antibody-secreting cells (ASCs) found in blood after antigen exposure, which can be used to identify an active antigen or pathogen causing illness.Composed of factors ...
Published: 5/24/2018       Inventor(s): Frances Lee, Ignacio (Inaki) Sanz, Doan Nguyen
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, inju...
Published: 3/23/2018       Inventor(s): Frank Anania, Pradeep Kumar
GeneRegs: Nanoparticles for Treatment of Severe Asthma
Application Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules. Key Benefits Specifically suppresses asthma associated inflammation. Easy self-administration by inhalation. Market Summary Asthma is defined as a chronic inflammatory lung disease with significant worldwide m...
Published: 12/4/2017       Inventor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
CIITA Deficient Human B Cell Line
ApplicationHuman B cell line deficient in class II transactivator (CIITA).Key BenefitsDeficient in CIITA.Useful for expression of tranfected MHC-II genes and alleles.Technical SummaryThe class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA in gene reg...
Published: 9/22/2017       Inventor(s): Jeremy Boss, Christopher (Chris) Scharer
Transgenic Mice for Studying Cell-Type Specific Immunity
ApplicationTransgenic mice expressing floxed mitochondrial antiviral-signaling protein (MAVS) for study of cell-type and tissue-specific immunity.Key BenefitsStudy cell-type and tissue-specific immunity.Can be crossed using CRE-recombinase system.Technical SummaryMitochondrial antiviral-signaling protein (MAVS) is a protein in humans that is encode...
Published: 6/26/2017       Inventor(s): Mehul Suthar
Small Molecules for the Treatment of Graft versus Host Disease
ApplicationAdministration of indole derivatives for the treatment of graft versus host disease.Key BenefitsDecreases incidence of GvHD after allogeneic transplantation.Does not create immuno-suppression in recipient.Market SummaryGraft versus host disease (GvHD) can arise following allogeneic transplantation, which is used for the treatment of dise...
Published: 6/7/2017       Inventor(s): Daniel Kalman, Edmund Waller, Cynthia Giver, Alyson Swimm, Sravanti Rangaraju
Derivatives as CXCR4 Modulators for the Treatment of Inflammation and Metastasis
ApplicationAmide derivatives as chemokine receptor type 4 (CXCR4) modulators for the treatment of inflammation or prevention of cancer cell metastasis.Key BenefitsExcellent binding affinity, compared to currently available compounds targeting CXCR4 receptor.Stability in plasma compared to protein/peptide agonists of CXCR4, these amide derivatives c...
Published: 4/24/2017       Inventor(s): Hyunsuk Shim, Renren Bai, Qi Shi
CXCR4 Modulator for Preventing Cancer Metastasis
Application Amine derivatives as chemokine receptor type 4 (CXCR4) modulators to treat breast cancer and block tumor metastasis. Key Benefits New class of anti-cancer drugs targeting CXCR4 instead of COX pathway. Partial antagonists are safer for use because they do not mobilize stem cells. Market Summary CXC chemokine receptor 4 (CXCR4) a...
Published: 4/10/2017       Inventor(s): Hyunsuk Shim, Renren Bai, Suazette Mooring
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