Non-radioactive Analogues of PiB for Detection of Aβ Plaques
ApplicationAβ tracer for non-radioactive detection useful for the early diagnosis of Alzheimer's disease.Key BenefitsNon-radioactive diagnostic method for detecting Aβ plaques in human AD.Readily conjugated with various non-radioactive reporter molecules.Also can be used for affinity capture or separation of modified Aβ structures th...
Inventor(s): Nicholas (nick) Seyfried, Ian Diner
Patch-Based Label Fusion for Automatic Prostate Segmentation in MR Images
ApplicationAn accurate automated method for prostate segmentation in magnetic resonance imaging (MRI).Key BenefitsYields faster results.Produces less subjective results compared to manual method.Market SummaryProstate cancer is the second leading cause of cancer death for USA male populations. Cancer indications have provided increased utility for ...
Inventor(s): Xiaofeng Yang, Tian Liu
Targeting Peptides for Myocarditis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Inventor(s): Michael Davis, Mario Martinez
Magnetic Resonance Based Pseudo-Computed Tomography (CT)
ApplicationSoftware for converting magnetic resonance (MR) images into pseudo-computed tomography (CT) images.Key BenefitsReduces patient exposure to radiation from X-rays.Simplifies diagnostic process by eliminating CT step.Reduces cost associated with performing both CT and MR.Eliminates misalignment errors associated with combined CT and MR appr...
Inventor(s): Xiaofeng Yang, Yang Lei, Tian Liu, Hui-kuo Shu, Peter Rossi
Bioluminescent Ion Indicator Proteins
ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synapt...
Inventor(s): Robert Gross, Ken Berglund, Jack Tung
Dual Purpose Radiotracer for Renal Imaging
ApplicationRadioactive tracer with improved plasma clearance for use as either a planar or positron emission tomography (PET) renal imaging agent.Key BenefitsRapid renal excretion.Minimal localization at other body sites.More rapid blood clearance than current standard.Can be adapted for either standard planar or positron emission tomography (PET) ...
Inventor(s): Jeffrey Klenc, Malgorzata Lipowska, Andrew Taylor
CXCR4-Targeting Molecules for Tumor Metastasis and PET Imaging
ApplicationPositron emission tomography (PET) imaging agents with high specificity for metastatic cancer.Key Benefits18F-labeled CXCR4 (partial) antagonist without stem cell mobilizing property is safe to be given to patient multiple times.Identifies tumor location non-invasively and provides an indication of tumor’s metastatic potential.Mark...
Inventor(s): Hyunsuk Shim, Mark Goodman, Dinesh Shetty, Yoon hyeun Oum
Theranostic Nanoparticles for Activation of Tumor-Specific Immune Responses
ApplicationTumor-targeted iron-oxide nanoparticle (IONP) composition for the delivery of anti-PD-L1 peptides for treatment of cancers.Key BenefitsTargeted delivery can reduce level of dosing and side effects.Peptides work by different mechanism than currently approved therapeutics.Added IONP core allows concurrent imaging during treatment.Nanoparti...
Inventor(s): Lily Yang, Erica Bozeman
Smart Start Treatment Planning
A knowledge-based brachytherapy treatment planning algorithm to tailor therapy plans to a physician’s specific preferences.
Tailors plans to physician preferences, increasing plan quality.
Decreases planning time, supporting real-time planning in the operating room.
Prostate cancer is fairly common i...
Inventor(s): Justin Roper, Eduard Schreibmann
Layer-by-layer Assembled Nanoparticles for Oral Drug Delivery
ApplicationLayered, casein coated magnetic nanoparticles for oral delivery of drugs protected from acid degradation.Key BenefitsEnables oral delivery of hydrophobic drugs that are sensitive to acid degradation in stomach condition. Replaces injections and infusions, reducing side effects and improving patient’s quality of life. Allows magneti...
Inventor(s): Hui Mao, Jing Huang