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Cost-Effective Catalysts for Industrial Chemical Applications
Application
A cost-effective catalyst for industrial chemical applications as an alternative to expensive rhodium-dependent dirhodium catalysts.
Key Benefits
Alternative catalysts to dirhodium using a straightforward synthesis process.
Preliminary data show the ability to self-assemble in a similar manner to dirhodium compounds.
Significantly...
Published: 3/1/2024
Contributor(s): Huw Davies, Joshua Sailer, Jack Sharland, Bo Wei
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CFTR Modulators for Treating Rare Forms of Cystic Fibrosis
Application
Small molecules to treat cystic fibrosis and other pulmonary diseases.
Key Benefits
Rescue rare variants of CFTR gene.
Serve as PDE4 inhibitors with strong anti-inflammatory effects.
Market Summary
Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...
Published: 4/8/2024
Contributor(s): Eric J. Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
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Chimeric Molecule for the Treatment of Depression
Application
Small molecules for treating depression and/or depression associated with cancer/chemotherapy.
Key Benefits
Potentially a dual mechanism compound – working via monoamine reuptake inhibition and HDAC inhibition (epigenetic modification).
Quicker acting compound compared to current therapies in the market. Works better than the...
Published: 1/31/2024
Contributor(s): Hyunsuk Shim, Huw Davies, Hyun Min Park, Yoon Hyeun Oum
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Small Molecule TAK-1 Inhibitors
Application
Small molecule inhibitors useful in the treatment of cancer and inflammatory diseases.
Key Benefits
TAK-1 activity can lead to metastasis and cancerous angiogenesis.
Suppression of TAK-1 has been demonstrated by a set of synthetic analogues based on the natural product 5(Z)-7-oxozeaenol.
Technical Summary
TAK1 is a member of the...
Published: 11/27/2023
Contributor(s): Huw Davies, Spandan Chenna Madhavuni, Andrei Bakin
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Cyclopropylamide Derivatives for Pain Management
ApplicationSmall molecules that can be used in the treatment of neuropathic pain. Key BenefitsCyclopropylamines have shown reduced side effects compared to other SNRIs for the treatment of neuropathic pain. Cyclopropylamine derivatives are more potent than other SNRI medication. Technical SummaryNeuropathic pain is a chronic/persistent state resulting...
Published: 4/8/2024
Contributor(s): Huw Davies, Spandan Chenna Madhavuni, Thomas Martin, Steven Childers
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Chiral Catalyst for Enantioselective Reactions of Aryl- and Styryldiazoacetates
Application
Catalysis of highly enantioselective cyclopropanations, tandem cyclopropanation/Cope rearrangements and combined C-H functionalization/Cope rearrangement reactions.
Key Benefits
Exhibits good tolerance to large ester groups for electron-withdrawing in high asymmetric induction.
Efficient reactions in dichlormethane allowing broader...
Published: 12/20/2023
Contributor(s): Changming Qin, Jorn Hansen, Huw Davies
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Steroid-Based Compounds for Targeting Cancer Cells
Application
Steroid-based vinyl diazo compounds for use in the treatment of cancer.
Key Benefits
Inhibits aromatase in a potent and specific manner.
Provides alternatives to the current medications that act as non-specific aromatase inhibitors.
Technical Summary
We have developed exemestane-based vinyl diazo compounds that act as aromatase...
Published: 4/8/2024
Contributor(s): Huw Davies, Daniel Morton, Debashis Ghosh
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