HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
Application
High Throughput Screening for identifying effective immuno-modulators.
Key Benefits
HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents.
Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 12/1/2023
Contributor(s): Xiulei Mo, Haian Fu
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KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
Application
Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells.
Key Benefits
First in class, targeted immunotherapy for patients presented with KRASG12V mutation.
Attenuates immune suppression associated with KRASG12V-positive cancers.
Market Summary
The KRASG12V mutation, representing 85% of all cancer mutations, is...
Published: 3/19/2024
Contributor(s): Haian Fu, Cong Tang, Xiulei Mo
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CFTR Modulators for Treating Rare Forms of Cystic Fibrosis
Application
Small molecules to treat cystic fibrosis and other pulmonary diseases.
Key Benefits
Rescue rare variants of CFTR gene.
Serve as PDE4 inhibitors with strong anti-inflammatory effects.
Market Summary
Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...
Published: 3/11/2024
Contributor(s): Eric J. Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
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14-3-3 Isoform Expression Vectors and Recombinant Proteins for use in Bioassays
Application
Expression vectors and recombinant proteins for use in 14-3-3 based bioassays and a variety of research applications.
Technical Summary
14-3-3 proteins are a family of phosphoserine/threonine recognition proteins that play important roles in diverse cellular processes, including cell proliferation, cell cycle progression, and apoptosis...
Published: 12/20/2023
Contributor(s): Haian Fu
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Cytotoxicity-Based Genetic Selection for Targeted Drug Screening
Applications
Screening method for drug discovery and investigating protein-protein interactions.
Technical Summary
Drug discovery is typically dependant on screening methods that involve negative selection, or the death of cell cultures when exposed to a specific drug. This invention, a cytoxicity-based genetic selection method (TOXSEL), introduces...
Published: 7/28/2023
Contributor(s): Raymond (Ray) Dingledine, John Collier, Haian Fu
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