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HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
­ Application High Throughput Screening for identifying effective immuno-modulators. Key Benefits HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents. Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 12/1/2023       Contributor(s): Xiulei Mo, Haian Fu
KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations, is...
Published: 3/19/2024       Contributor(s): Haian Fu, Cong Tang, Xiulei Mo
CFTR Modulators for Treating Rare Forms of Cystic Fibrosis
Application Small molecules to treat cystic fibrosis and other pulmonary diseases. Key Benefits Rescue rare variants of CFTR gene. Serve as PDE4 inhibitors with strong anti-inflammatory effects. Market Summary Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...
Published: 3/11/2024       Contributor(s): Eric J. Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
14-3-3 Isoform Expression Vectors and Recombinant Proteins for use in Bioassays
Application Expression vectors and recombinant proteins for use in 14-3-3 based bioassays and a variety of research applications. Technical Summary 14-3-3 proteins are a family of phosphoserine/threonine recognition proteins that play important roles in diverse cellular processes, including cell proliferation, cell cycle progression, and apoptosis...
Published: 12/20/2023       Contributor(s): Haian Fu
Cytotoxicity-Based Genetic Selection for Targeted Drug Screening
Applications Screening method for drug discovery and investigating protein-protein interactions. Technical Summary Drug discovery is typically dependant on screening methods that involve negative selection, or the death of cell cultures when exposed to a specific drug. This invention, a cytoxicity-based genetic selection method (TOXSEL), introduces...
Published: 7/28/2023       Contributor(s): Raymond (Ray) Dingledine, John Collier, Haian Fu