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Small Molecule Potentiators for Treatment of Central Nervous System Disorders
Application Series of compounds for selectively potentiating N-methyl-D-aspartate (NMDA) receptor subunit NR2C for treating central nervous system impairment. Key Benefits Selectivity for NR2C may reduce possibility of adverse side effects. Market Summary N-methyl-D-aspartate (NMDA) receptors are widely dispersed in the central nervous system...
Published: 4/23/2024       Contributor(s): Stephen Traynelis, Praseeda Mullasseril, Ethel Garnier-Amblard, Dennis Liotta, Sommer Zimmerman
Small Molecule Potentiators of NMDA Receptors for Treating Neurological Conditions
Application Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D. Key Benefits Small molecule potentiators enhance endogenous signals without exogenous activation. Subunit selectivity allows targeting of specific subtypes of...
Published: 7/28/2023       Contributor(s): Dennis Liotta, Ethel Garnier-Amblard, Gabriela Fernandez-Cuervo, Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Stephen Traynelis, Katie Strong, Rose Santangelo-Freel