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P-selectin Inhibitor for the Treatment of Sickle Cell Disease
Application
A glycopeptide inhibitor of p-selectin for the treatment of sickle cell disease.
Key Benefits
Blocks the activity of P-selectin with nM affinity.
Potential treatment for vaso-occlusive crisis associated with sickle cell disease.
Inhibits the earliest stage of leukocyte activation helping to prevent immune response.
Market Summary
Sickle...
Published: 4/8/2024
Contributor(s): Richard Cummings, Elliot Chaikof, Venkata Krishnamurthy, Mohammed Sardar
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B10 Protein Polymers to Build Arterial Vascular Grafts
Application
B10 protein polymers can be used to build small diameter arterial vascular grafts as well as a host of other potential cardiovascular constructs. The proteins may provide an important vehicle for the design of a variety of medically implanted devices.
Technical Summary
The emergence of genetically engineered synthetic polypeptides has...
Published: 11/6/2023
Contributor(s): Elliot Chaikof, Vincent Conticello
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Innovative Coatings to Improve Treatment of Type I Diabetes
Application
Coatings that protect islet cells during transplantation for the treatment of Type I diabetes.
Key Benefits
Ability to control permeability characteristics of shape conforming barrier coating.
Application to genetically engineered cells, neurons, cardiac myoblasts, myocardial cells, chondrocytes, dopamine secreting cells, or other...
Published: 7/28/2023
Contributor(s): Elliot Chaikof, Zhifei Dai, Wanxing Cui
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