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Small Molecules for the Treatment of Graft versus Host Disease ApplicationAdministration of indole derivatives for the treatment of graft versus host disease.Key BenefitsDecreases incidence of GvHD after allogeneic transplantation.Does not create immuno-suppression in recipient.Market SummaryGraft versus host disease (GvHD) can arise following allogeneic transplantation, which is used for the treatment of diseases... Published: 11/27/2023       Contributor(s): Daniel Kalman, Edmund Waller, Cynthia Giver, Alyson Swimm

Biologic Therapeutic for Graft-versus-Host Disease (GvHD) Application Biotherapeutic activation of toll-like receptor 5 (TLR5) to treat graft-versus-host disease (GvHD). Key Benefits Administration of flagellin reduces both acute and chronic GvHD. Contrary to immunosuppressive drugs, flagellin enhances immunity and protects patients from opportunistic infections. Market Summary Transplant recipients... Published: 11/6/2023       Contributor(s): Mohammad Hossain, Andrew Gewirtz, John Roback, Edmund Waller