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A 3D In Vitro Model of the Human Locus Coeruleus
Application
A brain organoid model for the human locus coeruleus to study its function and dysfunction in neurological diseases.
Key Benefits
Locus coeruleus region-specific neural organoid model for studying this deep region of the human brain.
The organoid synthesizes norepinephrine, allowing for study of diseases related to these neurotransmitters.
The...
Published: 4/8/2024
Contributor(s): Fikri Birey, David Weinshenker
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Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
Application
Improved study of neurodegenerative diseases on mice.
Key Benefits
Ability to study neuromelanin’s association with neurodegenerative diseases with mice.
Researchers can analyze overexpression of tyrosinase on specific cell types.
Market Summary
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 7/28/2023
Contributor(s): David Weinshenker, Alexa Iannitelli
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3q29 Deletion Mice
Application
Mouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders.
Technical Summary
Copy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most...
Published: 7/28/2023
Contributor(s): Tamara Caspary, David Weinshenker, Stephen Theodore Warren
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Transgenic Human Dopamine Beta-hydroxylase Mouse Model
Applications
Mouse model that utilizes a BAC to express human dopamine beta-hydroxylase in the brain.
Key Benefits
In vivo approach to dissect role of single genes in the nervous system.
May be used in the study of how human variants of dopamine beta-hydroxylase affect norepinephrine signaling in the brain.
Technical Summary
Dopamine beta-hydroxylase...
Published: 11/27/2023
Contributor(s): Joseph Cubells, David Weinshenker
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Hyperactive Rats
Application
Antidepressant drug screening for depression studies.
Technical Summary
We have developed different lines of rats by behavioral testing and then selective breeding of those showing desired characteristics in attempting to rat models for study of affective disorders. The lines were directed at possibly improving both drug screens (i.e.,...
Published: 7/28/2023
Contributor(s): Jay Weiss, Katherine Boss-Williams, David Weinshenker
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