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HIF/Hypoxia-Reporter Cell Lines
ApplicationHypoxia/Hypoxia-inducible factor 1 (HIF-1) inducible luciferase/LacZ reporter cell lines.Key BenefitExpression of luciferase and beta-galactosidase in response to hypoxia treatment.Technical SummaryEmory University researcher, Erwin Van Meir, has made HIF/hypoxia reporter cell lines by stably transfecting the cells with pBIGL-V6R-HRE-Luc...
Published: 1/22/2019       Inventor(s): Erwin Van Meir
ADGRB3/BAI3-Expressing Cell Lines
ApplicationADGRB3/BAI3 expressing human brain tumor cell lines.Technical SummaryAdhesion G protein coupled receptor B3 (ADGRB3), also called Brain-specific angiogenesis inhibitor 3 (BAI3) is a protein that in humans is encoded by the ADGRB3 gene. Emory University researcher Erwin Van Meir has developed medulloblastoma cell lines DAOY, UW288-1 and P...
Published: 1/22/2019       Inventor(s): Erwin Van Meir
Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to g...
Published: 3/26/2018       Inventor(s): Hyder Jinnah
CIITA Deficient Human B Cell Line
ApplicationHuman B cell line deficient in class II transactivator (CIITA).Key BenefitsDeficient in CIITA.Useful for expression of tranfected MHC-II genes and alleles.Technical SummaryThe class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA in gene reg...
Published: 9/22/2017       Inventor(s): Jeremy Boss, Christopher (Chris) Scharer
Spatiotemporal Genomic Analysis to Identify and Extract Rare Cancer Cells
ApplicationIsolation and analysis of phenotype and genome of rare cell types within a tumor for research and potential diagnostics.Key BenefitsAllows the identification of a single cell or group of cells within a tumor sample using phenotypic criteria.Enables both phenotypic and genetic analysis of the same rare cells within a tumor.Market SummaryF...
Published: 7/13/2017       Inventor(s): Adam Marcus, Jessica Konen
Immortalized Mouse Aortic Endothelial Cell Lines
Application Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research. Key Benefits Immortalized from mouse artery endothelial cells using polyoma middle T-antigen. Validated retention of primary endothelial markers and structural ...
Published: 3/25/2016       Inventor(s): Hanjoong Jo, Chih-Wen Ni, Sandeep Kumar
Prostate Cancer Cell Lines that Mimic Epithelial–Mesenchymal Transition
Application Prostate cancer cell lines that can undergo epithelial-mesenchymal transition to investigate metastatic biomarkers or screen therapeutics. Key Benefits Two genetically similar, but characteristically distinct prostate cancer cell lines that are either resistant or prone to metastasis. Mouse models injected with ARCaPE developed bone m...
Published: 6/21/2013       Inventor(s): Shumin Zhang, Lajos Gera, Daqing Wu
TrkA and TrkB Stably Transfected Murine Cell Lines
Application Cell lines (T17, T48, and T62) to screen for TrkA and/or TrkB agonists. Technical Summary Neurotrophins play an essential role in the development and maintenance of the nervous system. One such neutrophin, nerve growth factor (NGF) binds mainly tyrosine kinase A (TrkA). Docking of TrkA by NGF initiates receptor dimerization, phosphoryl...
Published: 6/6/2013       Inventor(s): Keqiang Ye
ARCaPE Cell Lines Expressing shRNAs of Human EPLIN
Application Highly malignant and metastatic prostate cancer cell line. Key Benefits Prostate cancer cell line with reduced Epithelial Protein Lost In Neoplasm (EPLIN) expression. Cell line exhibits morphology characteristics of malignant cell lines and increased chemoresistance, migration, and invasion. Market Summary Prostate cancer is the most...
Published: 5/28/2013       Inventor(s): Daqing Wu, Shumin Zhang
Pre-B Acute Lymphoblastic Leukemia Cell Line EU-4
Application Cancer cell line derived from a pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia with myeloid phenotype. Key Benefits Does not express p53 and expresses wild-type MDM2. Expresses wild-type Bax, over-expresses Bcl-xl, and does not express Bcl-2. Can be used as a tool for gene transfection assays in le...
Published: 5/24/2013       Inventor(s): Muxiang Zhou, Lubing Gu
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