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Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease. Key Benefits An immortalized caspase-3-deficient MEF cell line. Tool to study protease induced apoptosis. Technical Summary Emory inventors have discriminated a previously unknown role...
Published: 11/27/2023       Contributor(s): Lawrence Boise, Katelyn Ponder
HIF/Hypoxia-Reporter Cell Lines
Application Hypoxia/Hypoxia-inducible factor 1 (HIF-1) inducible luciferase/LacZ reporter cell lines. Key Benefit Expression of luciferase and beta-galactosidase in response to hypoxia treatment. Technical Summary Emory University researcher, Erwin Van Meir, has made HIF/hypoxia reporter cell lines by stably transfecting the cells with pBIGL-V6R-HRE-Luc/LacZ...
Published: 12/1/2023       Contributor(s): Erwin Van Meir
ADGRB3/BAI3-Expressing Cell Lines
ApplicationADGRB3/BAI3 expressing human brain tumor cell lines.Technical SummaryAdhesion G protein coupled receptor B3 (ADGRB3), also called Brain-specific angiogenesis inhibitor 3 (BAI3) is a protein that in humans is encoded by the ADGRB3 gene. Emory University researcher Erwin Van Meir has developed medulloblastoma cell lines DAOY, UW288-1 and PFSK1,...
Published: 12/1/2023       Contributor(s): Erwin Van Meir
Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout...
Published: 7/28/2023       Contributor(s): Hyder Jinnah
CIITA Deficient Human B Cell Line
Application Human B cell line deficient in class II transactivator (CIITA). Key Benefits Deficient in CIITA. Useful for expression of tranfected MHC-II genes and alleles. Technical Summary The class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA...
Published: 3/1/2024       Contributor(s): Jeremy Boss, Christopher (Chris) Scharer
Spatiotemporal Genomic Analysis to Identify and Extract Rare Cancer Cells
Application Isolation and analysis of phenotype and genome of rare cell types within a tumor for research and potential diagnostics. Key Benefits Allows the identification of a single cell or group of cells within a tumor sample using phenotypic criteria. Enables both phenotypic and genetic analysis of the same rare cells within a tumor. Market...
Published: 9/15/2023       Contributor(s): Adam Marcus, Jessica Konen
Immortalized Mouse Aortic Endothelial Cell Lines
Application Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research. Key Benefits Immortalized from mouse artery endothelial cells using polyoma middle T-antigen. Validated retention of primary endothelial markers and structural...
Published: 3/1/2024       Contributor(s): Hanjoong Jo, Chih-Wen Ni, Sandeep Kumar
ARCaPE Cell Lines Expressing shRNAs of Human EPLIN
Application Highly malignant and metastatic prostate cancer cell line. Key Benefits Prostate cancer cell line with reduced Epithelial Protein Lost In Neoplasm (EPLIN) expression. Cell line exhibits morphology characteristics of malignant cell lines and increased chemoresistance, migration, and invasion. Market Summary Although the survival...
Published: 3/1/2024       Contributor(s): Daqing Wu, Shumin Zhang
Pre-B Acute Lymphoblastic Leukemia Cell Line EU-4
Application Cancer cell line derived from a pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia with myeloid phenotype. Key Benefits Does not express p53 and expresses wild-type MDM2. Expresses wild-type Bax, over-expresses Bcl-xl, and does not express Bcl-2. Can be used as a tool for gene transfection assays in...
Published: 3/1/2024       Contributor(s): Muxiang Zhou, Lu Bing Gu
Early Pre-B Acute Lymphoblastic Leukemia Cell Line EU-1
Application Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia. Key Benefits Well-characterized continuous leukemia-lymphoma cell line. Expresses wild-type p53 and over-expresses MDM2 oncoprotein. Expresses wild-type Bcl-2, Bcl-xl, and Bax. Technical Summary p53 is...
Published: 3/1/2024       Contributor(s): Muxiang Zhou, Lu Bing Gu
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