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DHAA and Derivatives for Treatment of BRAF-V600E-Positive Cancer Application Hypolipidemic dehydroacetic acid (DHAA) treatment to prevent growth of BRAF V600E positive tumors. Key Benefits Treatment with slows BRAF V600E-positive tumor growth. Repurposed compound may speed FDA approval. May be used in combination with other therapies. Market Summary Up to 50% of melanoma cases harbor the BRAF V600E mutation,... Published: 11/27/2023       Contributor(s): Jing Chen, Jack Arbiser, Brian Pollack, Siyuan Xia

Repurposed Kinase Inhibitors as Vaccine Adjuvants Application Repurposed, small molecule kinase inhibitors, such as epidermal growth factor receptor (EGFR) inhibitors, as topical vaccine adjuvants. Key Benefits Improves immune response and efficacy of vaccines and vaccine candidates. Employs compounds that are already approved for human use. Market Summary In order to create long lasting protection... Published: 11/27/2023       Contributor(s): Brian Pollack, Richard Compans, Joanna Pulit-Penaloza, Ioanna Skountzou