14 Results Sort by:
Tension-activated Cell Tagging (TaCT)
Application A tool that measures cellular mechanical forces using flow cytometry. Key Benefits A fluorescently labeled approach based on the magnitude of molecular forces transmitted through cell adhesion receptors for evaluating mechanical forces in cells. A prototype has been developed showing proof -of-concept via the ability to determine mechanical...
Published: 1/10/2024       Contributor(s): Rong Ma, Khalid Salaita
Assays for Labeling and Evaluating Lysine Methylation
Application A life science tool for evaluating protein lysine methylation for drug discovery and disease research. Key Benefits Highly specific labeling method for post-translational methylated lysine. Potential to improve the understanding of protein lysine methylation and help develop new drugs to block its interactions across several disease...
Published: 3/1/2024       Contributor(s): Monika Raj, Ogonna Nwajiobi
Drug Screening System for Cardioprotection
Application A high throughput screening assay for developing therapies to protect from drug and alcohol-induced cardiotoxicity. Key Benefits A cardiovascular stem-cell-based screening assay that can identify drugs that protect the heart from toxic medications and alcohol. Preliminary data in the laboratory show the system is clinically relevant...
Published: 3/19/2024       Contributor(s): Chunhui Xu, Antonio Rampoldi, Yuhong Du
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
­ Application High Throughput Screening for identifying effective immuno-modulators. Key Benefits HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents. Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 12/1/2023       Contributor(s): Xiulei Mo, Haian Fu
Serological Test for SARS-CoV-2
­ Application Clinical assay for detecting SARS-CoV-2 neutralizing antibodies. Key Benefits Highly specific and sensitive. Fewer false positives than commercially available tests. Market Summary SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 12/20/2023       Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
Real-Time RT-PCR Assay for SARS-CoV-2
Application Triplex, internally-controlled real-time RT-PCR for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Two viral targets to confirm detection in a single sample. Does not involve the performance of multiple reactions as are required for the majority of published assays. May be performed using several different...
Published: 7/28/2023       Contributor(s): Jesse Waggoner
Ebola Specific Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) Assay
ApplicationA cell based assay to quantify the titer of circulating Ebola glycoprotein (GP) antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC).Key BenefitsSpecific for detection of ADCC activity of Ebola virus antibodies or antisera.Applicable to all pathogenic strains of Ebola virus.Ebola GP-specific stable reporter cells eliminate...
Published: 1/17/2024       Contributor(s): Paul Spearman, Karnail Singh, Xuemin Chen
Assay to Measure Cell Traction Forces for High Throughput Drug Screening and Mechanical Phenotyping
Application Mechanically induced catalytic amplification reaction (MCR) as an assay for high throughput screening of drugs which target cellular mechanics and mechanical phenotyping of live cells. Key Benefits Adaptable for high throughput screening of drugs that impair cell mechanics. Enables characterization of different cells types based on...
Published: 11/27/2023       Contributor(s): Pui Yan Ma, Khalid Salaita
Tool for Measuring Cell Purity and Quality Control of Stem Cell-based Products
Application Cell-based assay for sensitive and specific detection of undifferentiated cells in stem cell-related research and development. Key Benefits Nanotechnology-based assay can detect residual undifferentiated cells and characterize cultures that may be tumorigenic. Technology is potentially more sensitive method compared to current methods. Market...
Published: 11/27/2023       Contributor(s): Chunhui Xu, Shuming Nie, Ximei Qian, Jingjia Han
Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses
Application A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated. Key Benefits Potent (sub-nM range), non-peptidic, non-nucleosidic compounds. Robust, cell-based, high-throughput screening assay. Technical Summary Vaccination serves...
Published: 11/6/2023       Contributor(s): Richard Plemper, James Snyder, Aiming Sun
1 2