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Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies Application Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients. Key Benefits Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese... Published: 1/10/2024       Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross

Multi-Target CCR5/CXCR4 Chemokine Compounds for the Treatment of HIV Application Chemical compounds that bind to both CCR5 and CXCR4 chemokine GPCRs as therapeutics to block HIV entry and infection. Key Benefits Targets both chemokine receptors used for cell entry by HIV: CCR5 & CXCR4. Eliminates the requirement of a tropism pre-test used for drug administration of single chemokine agents. Does not interfere... Published: 4/8/2024       Contributor(s): Bryan Cox, Lawrence (larry) Wilson, Anthony Prosser, James Snyder, Dennis Liotta