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Human Brain Proteins with Evidence Consistent with Causality of Alzheimer’s and Depression
Application
Research and therapeutic targets for Alzheimer’s disease, depression, and other neurological conditions mediated by protein expression in the brain.
Key Benefits
These findings can be utilized as a research tool to better understand the genetic basis of Alzheimer’s disease.
Can also be utilized to develop therapeutics for...
Published: 4/23/2024
Contributor(s): Aliza Wingo, Thomas Wingo, Yue Liu, Allan Levey, Nicholas Seyfried, Duc Duong
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RNA Biomarkers for Alzheimer’s Disease
Application
RNA for U1 small nuclear ribonucleoprotein (snRNP) subunits as biomarkers for Alzheimer’s disease (AD).
Key Benefits
Identifies unique U1 snRNP pathology in AD patients that implicates abnormal RNA splicing in AD pathogenesis.
Facilitates early diagnosis and intervention strategies for treatment of AD.
Potential use as therapeutic...
Published: 4/23/2024
Contributor(s): Allan Levey
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ß-secretase (BACE) Monoclonal Antibody
Applications
Immunohistochemistry
Western Blot
Immunprecipitation
Specificity
β -secretase (BACE) of mouse, rat, and human origin.
Subtype
Mouse Monoclonal
Technical Summary
β -secretase (BACE) is an aspartic-acid protease important to the formation of the amyloid-β peptides that form senile plaques in brains of Alzheimer's...
Published: 4/23/2024
Contributor(s): Allan Levey
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Presenillin 1 N-Terminal Monoclonal Antibody
Applications
Immunoblotting
Immunocytochemistry
Specificity
Human Presenilin-1 N-terminal
Subtypes
Rat monoclonal
Technical Summary
By immunoblotting applications the antibody recognizes a predominant 32 kDa polypeptide in a varitety of samples including PC12 cells transfected with human PS1, complimentary DNA brain biopsy specimens from...
Published: 4/23/2024
Contributor(s): Allan Levey
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Presenillin 1 C-Terminal Monoclonal Antibody
Applications
Immunoblotting
Immunohistochemistry
Specificity
Human Presenilin-1 C-terminal
Subtypes
Mouse Monoclonal
Technical Summary
By immunoblotting applications the antibody recognizes a predominant 32 kDa polypeptide in a varitety of samples including PC12 cells transfected with human PS1, complimentary DNA brain biopsy specimens from...
Published: 4/23/2024
Contributor(s): Allan Levey
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Monoclonal Antibody for High-Affinity Choline Transporter
Application
Immunocytochemistry
Western Blot
Immunoprecipitation
Specificity
Human, rat & mouse high-affinity choline transporter (CHT). No detectable cross reactivity with other proteins by western blot.
Subtype
Mouse IgG1 (monoclonal)
Technical Summary
Acetylcholine functions as a neurotransmitter in both the central and peripheral...
Published: 4/23/2024
Contributor(s): Allan Levey, Randy Blakely, Craig Heilman
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Muscarinic Acetylcholine Receptor m2 Antibody
Applications
Immunohistochemistry
Western blotting
Specificity
m2 muscarinic acetylcholine receptor
Subtype
Rat Monoclonal
Technical Summary
The m2 muscarinic acetylcholine receptor is a membrane bound G-protein coupled receptor highly expressed throughout the basal forebrain, as well as in cardiac tissue. These monoclonal antibodies were...
Published: 3/1/2024
Contributor(s): Allan Levey, Craig Heilman
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