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Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses
Application
A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated.
Key Benefits
Potent (sub-nM range), non-peptidic, non-nucleosidic compounds.
Robust, cell-based, high-throughput screening assay.
Technical Summary
Vaccination serves...
Published: 11/6/2023
Contributor(s): Richard Plemper, James Snyder, Aiming Sun
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Novel Inhibitors of NOX2/ROS
Applications
Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD).
Key Benefits
NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications.
Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases.
Technical...
Published: 7/28/2023
Contributor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
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Small Molecule Non-Nucleoside Inhibitors of the Measles Viruses
Application
Small molecule measles virus RNA Dependent RNA Polymerase (RDRP) inhibitors.
Key Benefits
Potent (nM) non-nucleoside small molecule inhibitors of the measles virus RDRP protein.
No current drug therapy for measles.
Market Summary
The target market for this therapeutic agent is in the developing world where measles has been known...
Published: 4/8/2024
Contributor(s): Richard Plemper, James Snyder, Aiming Sun, John Maina Ndungu, Jeong-Joong Yoon
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Small Molecule Inhibitors Show Promise with RNA Viruses
Application
Potent small molecule inhibitors of RNA viruses that cause many highly contagious and dangerous diseases such as canine distemper, RSV, influenza, and measles.
Key Benefits
Inhibits measles, canine distemper, human parainfluenza, and influenza A viruses.
May be used for the management of a disease and for rapid control of possible...
Published: 1/25/2024
Contributor(s): Richard Plemper, James Snyder, Aiming Sun, John Maina Ndungu, Jeong-Joong Yoon
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