Trimeric Immunogen for HIV-1 Vaccination
Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine.
Possible oral administration.
Broadly cross-reactive against HIV-1 panel.
Promotes antibody responses as both a primary immunogen and boosting immunogen.
Antiretroviral therapy (ART) has dramatically prol...
Inventor(s): Rama Amara, Andrew Jones, Raghavan Varadarajan, Sannula Kesavardhana
Glycoprotein Tetramer for Identifying Antigen-specific B Cells
ApplicationEctodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.Key BenefitsViral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.Market SummaryHepatiti...
Inventor(s): Arash Grakoui, Joseph Marcotrigiano
ApplicationStandalone smartphone app to increase vaccinations and improve vaccine knowledge for providers, pharmacists, and the general public.Key BenefitsProvides detailed information about a variety of vaccines and diseases. Sends out alerts and updates. Market SummaryVaccines prevent millions of cases of infectious diseases each year; however, m...
Inventor(s): Saad Omer, Robert Bednarczyk, Paula Frew, Walter Orenstein, Ines Gonzalez-Casanova, Neal Halsey, Daniel Salmon
Human Monoclonal Antibodies Against Ebola Virus
ApplicationAntibodies that bind and neutralize Ebola virus glycoprotein (GP) for use in vaccination or treatment of Ebola virus disease.Key BenefitsHigher binding affinity for Ebola virus GP than closest competitor.Can be used prophylactically or for treatment of Ebola virus disease.Market SummaryThe Ebola virus is an RNA virus with a membrane comp...
Inventor(s): Rafi Ahmed
Respiratory Syncytial Virus (RSV) A2 Expressing Firefly Luciferase
ApplicationRecombinant RSV strain expressing firefly luciferase and the F & G genes from clinical strain A2001/2-20 for research and development of vaccines.Key BenefitsF & G proteins included in this strain show different behavior than those of the typical A2 strain proteins.May be adapted in a variety of assays, enabling the identificatio...
Inventor(s): Martin Moore, Christopher Stobart
Helper Plasmids for Rescue of Respiratory Syncytial Virus
ApplicationPlasmids rescuing recombinant syncytial virus for RSV research and vaccine development.Key BenefitsAllow expression and recombination in vero cells.Optimized for human codon bios to increase expression in mammalian cells.Market SummaryRespiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in infa...
Inventor(s): Martin Moore
Plasmid for Respiratory Syncytial Virus (RSV) Vaccine Development & Research
ApplicationsBacterial artificial chromosome (BAC) plasmid containing the antigenomic sequence A2-BAG-BAF derived from multiple strains of RSV. Key BenefitsViral DNA is contained in a BAC, allowing for efficient mutagenesis and recombineering of viral DNA. BAC is stable and can be used for cloning in common bacteria types like E. coli.Provides power...
Inventor(s): Martin Moore, Anne Hotard (Lopez-Ona)
Recombinant Respiratory Syncytial Virus (RSV) Firefly Luciferase Reporter Strain
ApplicationModified recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development.Key BenefitsProvides a new high throughput screening tool for RSV vaccine development and drug discovery.Firefly luciferase based assays show better signal-to-noise than fluorescence-based a...
Inventor(s): Richard Plemper, Martin Moore
Membrane-anchored Fusokine as Vaccine Adjuvant to Prevent Viral Infection
ApplicationGIFT4 anchored to virus-like particles (VLPs) as a prophylactic vaccine adjuvant to prevent chronic viral infections including HIV, HBV, HPV and influenza.Key BenefitsGIFT4-containing VLPs induce higher antibody response than non-adjuvanted VLPs. Effectively induce strong mucosal immune response. Market SummaryMore than 36 million people...
Inventor(s): Baozhong Wang, Richard Compans, Jacques Galipeau, Jiusheng Deng
Broad Spectrum Vaccine to Human Rhinovirus Serotypes
A vaccine that provides protection from a broad spectrum of human rhinovirus serotypes.
Targets numerous, specific human rhinovirus (HRV) serotypes and provides broad neutralizing antibodies.
Engineered bacterial artificial chromosome (BAC) expression of HRV to reproducibly express specific serotypes.
BAC system allows f...
Inventor(s): Martin Moore, Minh Nguyen, Sujin Lee