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GeneRegs: Nanoparticles for Treatment of Severe Asthma
ApplicationGold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules.Key BenefitsSpecifically suppresses asthma associated inflammation.Easy self-administration by inhalation.Market SummaryAsthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity. Curre...
Published: 12/4/2017       Inventor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
Micron-Sized Drug Vehicle for Unregulated Blood Clotting
ApplicationFibrinogen-coated micron-sized drug vehicles for targeted treatment of unregulated blood clotting.Key BenefitsFacilitates targeted release of drugs specifically for blood clotting disorders.Drug delivery vehicle can be used with newly discovered or known therapeutics on the market.Site specific biological mechanism may help increase drug...
Published: 2/20/2017       Inventor(s): Caroline Hansen, Yumiko Sakurai, Wilbur Lam, Andrew Lyon
Microfluidic Device for Increased Viral Transduction Efficiency
ApplicationMicrofluidic chip device for facilitating high throughput viral transduction for gene therapy applications.Key BenefitsImproves surface-to-volume ratio, allowing more efficient contact between lentiviruses and cellsIncreases efficiency while maintaining cell viability of traditional methods.Enables gene transfer for non-adherent cells.Co...
Published: 2/7/2017       Inventor(s): Reginald Tran, Wilbur Lam, David Myers, Christopher Doering, H. trent Spencer
Anti-biofouling Polymer for Nanoparticle Coating
Application A functionally amenable copolymer of polyethylene glycol (PEG) and allyl glycidyl ether (AGE) that improves the specificity and targeting of nanoparticles compared to PEG coating. Key Benefits Amphiphilic properties significantly reduce non-specific adsorbtion of proteins compared to PEG. Improves targeting and cell-specific uptake o...
Published: 6/1/2016       Inventor(s): Hui Mao, Yuancheng Li, Lily Yang
Layer-by-layer Assembled Nanoparticles for Oral Drug Delivery
ApplicationLayered, casein coated magnetic nanoparticles for oral delivery of drugs protected from acid degradation.Key BenefitsEnables oral delivery of hydrophobic drugs that are sensitive to acid degradation in stomach condition. Replaces injections and infusions, reducing side effects and improving patient’s quality of life. Allows magneti...
Published: 4/27/2015       Inventor(s): Hui Mao, Jing Huang
Ultrafine Oligosaccharide-Coated Iron Oxide Nanoparticles
ApplicationUltrafine magnetic iron oxide nanoparticles (IONPs) coated in oligosaccharides for enhanced contrast in magnetic resonance imaging (MRI).Key BenefitsOligosaccharide coating is biocompatible. Coating leads to increased water solubility and solution stability. Small size promotes a high efficiency contrast enhancement for MRI that can diff...
Published: 4/27/2015       Inventor(s): Hui Mao, Jing Huang
Collagen-Mimetic Nanosheets
Application Two-dimensional sheets composed of collagen-mimetic peptides on the nanoscale that are highly-ordered and self-assembling. Key Benefits Thermal stability, sheet thickness, and sheet dimensions can be controlled through the peptide sequence and preparative conditions. Market Summary Collagens are used in a number of consumer and biomed...
Published: 5/7/2014       Inventor(s): Vincent Conticello, Tao Jiang
Acid-Sensitive Nanoparticles for Encapsulation and Delivery of Highly Potent Anticancer Agents
Application Nanoparticle drug delivery vehicles that maintain potency yet diminish toxicity of maytansinoids as cancer therapeutics. Key Benefits Reduces cancer metastasis and could be used as a prophylactic treatment. Acts as a delivery vehicle for maytansinoids that simultaneously maintain potency, increase efficacy, and diminish toxicity. Sho...
Published: 2/25/2014       Inventor(s): Yiqing Wang, Shuming Nie
LED Emitting Silica Nanoparticles
Application LED dye-linked silica nanoparticles with tunable size for imaging applications. Key Benefits Incorporation of a naphthalimide derivative greatly enhances photostability and increases pH tolerance. Large size range and easily tunable. Excited by visual light, 450-495 nm (blue) & emits visual wavelength, 545 nm (green). Particle c...
Published: 7/15/2013       Inventor(s): George Beck, jr., Mervyn (neale) Weitzmann, Shin woo Ha, Jin-kyu Lee, Hak-sung Jung
A Multifunctional Nanoparticle siRNA Delivery System
Application Tumor receptor-targeted nanoparticle containing a siRNA DNA cassette for the knockdown of survival genes and treating cancer. Key Benefits Nanoparticles are targeted directly to tumors for treatment and/or diagnostic imaging. siRNA encoded by a DNA cassette has increased stability and more effective gene depletion. siRNA knockdown o...
Published: 3/27/2013       Inventor(s): Lily Yang
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