Small Molecule Inhibitors of Mcl-1 as Anti-Cancer Agent
ApplicationMyeloid cell leukemia 1 (Mcl-1) inhibitor to enhance DNA replication stress sensitivity for cancer therapy.Key BenefitsInhibits DNA repair in cancer cells.Used in combination with existing cancer therapy.Market SummaryChemoresistance occurs when cancer cells develop resistance to chemotherapy drugs, and appearance of chemoresistance grea...
Inventor(s): Xingming Deng, Guo Chen, Abu Syed Md Anisuzzaman
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax.
Co-therapy increases MM sensitivity to venetoclax treatment.
Identifies patients who will respond to venetoclax therapy.
Multiple Myeloma (MM) is a cancer of plasma cells responsible for making ant...
Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Small Molecule Inhibitors of NADPH Oxidase 4 (NOX4) Signaling
ApplicationSmall molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential.Key BenefitsSmall molecule inhibitors of NOX4 signaling.Low cytotoxicity.Market SummaryThe NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of diseases, som...
Inventor(s): Bernard Lassegue, Kathy Griendling, David Brown, Qian Xu, Osman Guner, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
Glycolysis Inhibitors as Potential Cancer Therapeutics
ApplicationA new potential anti-cancer agent that inhibits the glycolytic enzyme PGAM1 and thereby tumor growth.Key BenefitsTargets tumor metabolism by inhibiting glycolytic enzyme and turning off tumor metabolism.Inhibition of glycolytic enzyme (PGAM1) by these inhibitors leads to significant reduction in tumor growth.Market SummaryTreating cancer...
Inventor(s): Jing Chen, Taro Hitosugi, Sumin Kang
Liver Receptor Homolog 1 (LRH-1) Agonist for the Treatment of Type 2 Diabetes and Inflammatory Bowel Disease
ApplicationSmall molecule agonist that changes the expression of LRH-1 genes involved with lipid metabolism and inflammation.Key BenefitsLess toxic and more potent molecule compared to known LRH-1 agonists.More soluble compound that improves its pharmacokinetics (PK).Market SummaryLiver receptor homolog 1 (LRH-1) is a nuclear hormone receptor that ...
Inventor(s): Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
Cancer Cell Metabolism Inhibitors for Targeted Therapies
ApplicationGlutamate dehydrogenase (GDH1) inhibitors targeting cancer cell metabolic pathways.Key BenefitsTargets tricarboxylic acid (TCA) cycle/mitochondrial metabolism utilized by several cancer cell types for cell growth and survival.Reduces cell proliferation and viability in several tumor derived cell lines as well as in xenograft tumor models...
Inventor(s): Sumin Kang, Jing Chen, Lingtao Jin
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
ApplicationSmall molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.Key BenefitsProduces highly-enriched, subtype-specific populations of cardiac myocytes.Eliminates need for cell-sorting.Does not require transgenic changes to the human stem cells.Market Summ...
Inventor(s): Hee Cheol Cho, Pengcheng Han
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, inju...
Inventor(s): Frank Anania, Pradeep Kumar
Desulfitative Redox Catalysis Method for Production of Amide and Peptide Linkages
ApplicationAn efficient and economic catalytic process for forming amide and peptide compounds.Key BenefitsUses more inexpensive reagents compared to other methods.Amide/peptide bond is generated in high yield at or near ambient temperature.Mild reaction conditions prevent generation of impurities.Market SummaryPeptide and amide linkages are import...
Inventor(s): Lanny Liebeskind, Matthew Lindale
Assay to Measure Cell Traction Forces for High Throughput Drug Screening and Mechanical Phenotyping
ApplicationMechanically induced catalytic amplification reaction (MCR) as an assay for high throughput screening of drugs which target cellular mechanics and mechanical phenotyping of live cells.Key BenefitsAdaptable for high throughput screening of drugs that impair cell mechanics.Enables characterization of different cells types based on their tr...
Inventor(s): Pui Yan Ma, Khalid Salaita