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Cancer Cell Metabolism Inhibitors for Targeted Therapies
ApplicationGlutamate dehydrogenase (GDH1) inhibitors targeting cancer cell metabolic pathways.Key BenefitsTargets tricarboxylic acid (TCA) cycle/mitochondrial metabolism utilized by several cancer cell types for cell growth and survival.Reduces cell proliferation and viability in several tumor derived cell lines as well as in xenograft tumor models...
Published: 12/6/2018       Inventor(s): Sumin Kang, Jing Chen, Lingtao Jin
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
ApplicationSmall molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.Key BenefitsProduces highly-enriched, subtype-specific populations of cardiac myocytes.Eliminates need for cell-sorting.Does not require transgenic changes to the human stem cells.Market Summ...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Pengcheng Han
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, inju...
Published: 3/23/2018       Inventor(s): Frank Anania, Pradeep Kumar
Desulfitative Redox Catalysis Method for Production of Amide and Peptide Linkages
ApplicationAn efficient and economic catalytic process for forming amide and peptide compounds.Key BenefitsUses more inexpensive reagents compared to other methods.Amide/peptide bond is generated in high yield at or near ambient temperature.Mild reaction conditions prevent generation of impurities.Market SummaryPeptide and amide linkages are import...
Published: 11/16/2017       Inventor(s): Lanny Liebeskind, Matthew Lindale
Small Molecules for Treating Cystic Fibrosis
ApplicationSmall molecule compounds to potentiate most common type of CFTR mutation in cystic fibrosis patients.Key BenefitsPotentiates ΔF508-hCFTR mutation, addressing more than 60 percent of CF patients. Market SummaryCystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and ion channel that malfunctions in the ge...
Published: 9/18/2017       Inventor(s): Nael Mccarty, Guiying Cui, Hanoch Senderowitz, Netaly Khazanov
Assay to Measure Cell Traction Forces for High Throughput Drug Screening and Mechanical Phenotyping
ApplicationMechanically induced catalytic amplification reaction (MCR) as an assay for high throughput screening of drugs which target cellular mechanics and mechanical phenotyping of live cells.Key BenefitsAdaptable for high throughput screening of drugs that impair cell mechanics.Enables characterization of different cells types based on their tr...
Published: 6/26/2017       Inventor(s): Pui Yan Ma, Khalid Salaita
Repurposed Kinase Inhibitor for Treatment of Multidrug Resistant Tuberculosis
ApplicationProtein tyrosine kinase inhibitor (imatinib) used as a treatment to prevent multiple drug-resistant tuberculosis lethality and latent reactivation.Key BenefitsEffective against drug resistant strains of tuberculosis.May be used in combination with current first-line treatments of TB.Market SummaryTuberculosis (TB) is a chronic infectious...
Published: 6/20/2017       Inventor(s): Daniel Kalman
CXCR4 Antagonists for the Treatment of Cancer
ApplicationSmall molecules containing either the piperidine or piperazine core which act as antagonists to C-X-C chemokine receptor type 4 (CXCR4) and may be orally administered.Key BenefitsOrally administered CXCR4 antagonists with diverse clinical applications in oncology.Mobilize white blood cells in mice in a dose-dependent manner.Cause apoptos...
Published: 4/27/2017       Inventor(s): Lawrence (larry) Wilson, Dennis Liotta, John Wiseman, Michael Natchus
Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses
Application A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated. Key BenefitsPotent (sub-nM range), non-peptidic, non-nucleosidic compounds. Robust, cell-based, high-throughput screening assay. Technical Summary Vaccination serves as the ...
Published: 10/18/2016       Inventor(s): Richard Plemper, James Snyder, Aiming Sun
Small Molecule Potentiators for Treatment of Central Nervous System Disorders
ApplicationSeries of compounds for selectively potentiating N-methyl-D-aspartate (NMDA) receptor subunit NR2C for treating central nervous system impairment.Key BenefitsSelectivity for NR2C may reduce possibility of adverse side effects.Market SummaryN-methyl-D-aspartate (NMDA) receptors are widely dispersed in the central nervous system (CNS) and ...
Published: 10/17/2016       Inventor(s): Stephen Traynelis, Praseeda Mullasseril, Ethel Garnier-Amblard, Dennis Liotta, Sommer Zimmerman
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